GENETICS

Hemophilia A pedigree.

This pedigree illustrates a common X-linked recessive inheritance pattern for hemophilia A. Carrier females are marked separately from affected males, making the route through generations easy to follow. An unaffected father and carrier mother can have affected sons, carrier daughters and unaffected children. The carrier daughter in the next generation then has an affected son, which makes the pattern visible without adding unnecessary detail. Clinicians and students use examples like this to discuss why family history matters and which relatives may need assessment. The chart records reported status; it does not establish a diagnosis or replace factor testing and genetic counseling.

UPDATED 2026-09-24
EXAMPLEHemophilia A pedigree.
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CASE ANALYSIS

Scenario

Genetic counseling

Key decisions

  • X-linked carrier: The mother carries the altered X chromosome.
  • Affected males: Two sons show the condition.
  • Transmission: A carrier daughter can pass the variant to a son.

When to reuse this

Use this pedigree to explain the typical X-linked recessive pattern in a family history.

FAQ

Frequently asked questions

Why are males more often affected?01
Males have one X chromosome, so one disease-associated change on it can cause an X-linked recessive condition.
What does carrier-x mean?02
It marks a female who carries a disease-associated variant on one X chromosome.
Can an unaffected male pass hemophilia A to his son?03
No. A father passes a Y chromosome, not his X chromosome, to a son.
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