Die Anfrage
“A Huntington disease pedigree: an affected father and unaffected mother have an affected daughter and an unaffected son; the affected daughter and an unaffected partner have an affected daughter who is the proband and an unaffected son.”
Dann probieren SieAdd age of onset below the affected relatives.Mark the affected daughter in generation two as deceased.
Was diese Zeichnung zeigt
Die dahinterstehenden Entscheidungen verstehen.
01Successive generations
Affected relatives appear in each generation.
02Unaffected partners
Partners are shown as unaffected.
03Index case
The affected granddaughter is the proband.
Use this simple chart to introduce autosomal dominant inheritance in a counseling or teaching conversation.
FAQ
Häufige Fragen
What is autosomal dominant inheritance?
A disease-associated variant on a non-sex chromosome can be sufficient to cause the condition.
Why are unaffected relatives included?
They show the family structure and help make the inheritance pattern easier to interpret.
What does the arrow identify?
It marks the proband, the person who prompted the clinical evaluation.