GENETICS

Huntington disease pedigree.

This simple pedigree shows an autosomal dominant pattern using Huntington disease as the clinical example. An affected parent has an affected child in the next generation, while unaffected relatives are also shown so the family structure is easy to read. The affected granddaughter is the proband, the person whose history brought the family to clinical attention. This is the kind of compact drawing used early in a consultation or in genetics teaching, before dates, test reports and additional relatives are added. A pedigree shows reported family history and relationships; it cannot determine whether a person has inherited a variant. Genetic testing and medical decisions should be discussed with a qualified clinician or counselor.

UPDATED 2026-09-24
EXAMPLEHuntington disease pedigree.
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CASE ANALYSIS

Scenario

Genetic counseling

Key decisions

  • Successive generations: Affected relatives appear in each generation.
  • Unaffected partners: Partners are shown as unaffected.
  • Index case: The affected granddaughter is the proband.

When to reuse this

Use this simple chart to introduce autosomal dominant inheritance in a counseling or teaching conversation.

FAQ

Frequently asked questions

What is autosomal dominant inheritance?01
A disease-associated variant on a non-sex chromosome can be sufficient to cause the condition.
Why are unaffected relatives included?02
They show the family structure and help make the inheritance pattern easier to interpret.
What does the arrow identify?03
It marks the proband, the person who prompted the clinical evaluation.
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