PATHOPHYSIOLOGY

Heart failure fluid retention loop

This diagram presents one simplified feedback pattern in heart failure. A fall in cardiac output can reduce renal perfusion, which can increase RAAS activation and promote sodium and water retention. Retention can raise circulating volume and preload, contributing to pulmonary congestion; congestion can in turn worsen cardiac output. The diagram makes the direction of each relationship explicit and names the resulting reinforcing loop. It omits many important compensatory, treatment and patient-specific factors so that the core pattern remains readable. Use it in teaching or discussion as a starting point, and add a balancing loop only when its causal links are clear. It is not a clinical model for assessing or treating an individual patient.

UPDATED 2026-09-24
EXAMPLEHeart failure fluid retention loop
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CASE ANALYSIS

Scenario

Heart failure teaching

Key decisions

  • Variables: Keep haemodynamic states distinct.
  • Polarity: Show lower renal perfusion increasing RAAS activation.
  • Loop: Trace retention through congestion to output.
  • Scope: Present this as a simplified mechanism.

When to reuse this

Use for education, not individual treatment decisions.

FAQ

Frequently asked questions

What does RAAS activation represent?01
It represents hormonal responses to reduced renal perfusion that can promote sodium and water retention.
Why is the loop reinforcing?02
Reduced output can lead to retention and congestion that can further reduce output.
Can treatment be added?03
Yes, a diuretic or other intervention can be modelled as a balancing influence for teaching.
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