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Cardiology · Neonatology · Clinical Algorithms

Neonatal Hyperoxia Test Algorithm for Duct-Dependent Lesions

Type FlowchartStandard Sugiyama layered DAG + orthogonal routingEngine schematex-flowchartUpdated 7/14/2026
Neonatal Hyperoxia Test Algorithm for Duct-Dependent Lesions
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The scenario

Algorithm to guide diagnostic and therapeutic decisions in neonates with hypoxemia suspected to have duct-dependent congenital heart disease.

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Read the decisions behind it.

01Interpretation of PaO2 after hyperoxia test

>150 mmHg likely non-cardiac, <100 mmHg likely cyanotic CHD.

02

Echocardiographic identification of duct-dependent lesions such as HLHS, TGA, or PA/IVS.

03

Immediate start of prostaglandin E1 infusion if duct-dependent lesion confirmed.

Emergency departments, NICUs, and general pediatric wards evaluating cyanotic newborns, especially in settings where echocardiography is available.

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