Sepsis inflammatory response loop

This causal loop diagram simplifies a harmful feedback pattern in sepsis. Infectious burden can increase inflammatory response, which can increase vascular permeability. As intravascular volume falls, tissue perfusion may fall and organ dysfunction may rise. Organ dysfunction can then add to the inflammatory response. The diagram is designed to help learners follow the direction of relationships rather than memorise a list of effects. It leaves out timing, microbial causes, patient variation and the many interventions used in clinical care. Use it as a classroom or discussion aid, and ensure any clinical decisions follow current local guidance and professional judgement. A causal loop is qualitative; it does not predict severity for an individual.