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pathophysiology · critical care

Sepsis inflammatory response loop

This causal loop diagram simplifies a harmful feedback pattern in sepsis. Infectious burden can increase inflammatory response, which can increase vascular permeability. As intravascular volume falls, tissue perfusion may fall and organ dysfunction may rise. Organ dysfunction can then add to the inflammatory response. The diagram is designed to help learners follow the direction of relationships rather than memorise a list of effects. It leaves out timing, microbial causes, patient variation and the many interventions used in clinical care. Use it as a classroom or discussion aid, and ensure any clinical decisions follow current local guidance and professional judgement. A causal loop is qualitative; it does not predict severity for an individual.

Type Diagramme causalNorme Sterman, Business Dynamics (2000)Moteur schematex-causalloopMis à jour 24/09/2026
Sepsis inflammatory response loop
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La demande

“Create a causal loop diagram for sepsis with infectious burden, inflammatory response, vascular permeability, intravascular volume, tissue perfusion and organ dysfunction. Show the reinforcing loop in which inflammation contributes to hypoperfusion and organ dysfunction that further increases inflammation.”

Essayez ensuiteAdd fluid resuscitation as a balancing loopAdd antimicrobial treatment
Ce que contient ce dessin

Comprenez les décisions qui le sous-tendent.

01Variables

Separate inflammation from infection.

02Polarity

Track the loss of intravascular volume.

03Loop

Connect organ dysfunction back to inflammation.

04Scope

Avoid using it as a treatment protocol.

Use as an educational overview of one sepsis mechanism.

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FAQ

Questions fréquentes

Why is intravascular volume linked negatively to permeability?

Greater permeability can move fluid out of the vascular space, reducing circulating volume.

What does the loop show?

It shows a potential self-worsening relationship between inflammation, hypoperfusion and organ dysfunction.

Can antibiotics be added?

Yes, antimicrobial treatment can be shown as reducing infectious burden in a teaching extension.