“A BRCA1 hereditary cancer pedigree: an unaffected man and a deceased affected woman have an affected daughter, an unaffected son and a carrier daughter; the affected daughter has an affected daughter who is the proband, an unaffected son and a presymptomatic daughter; the carrier daughter has a carrier daughter and an unaffected son.”
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Cancer appears in successive generations.
The affected granddaughter is the proband.
Carrier and presymptomatic relatives are distinguished.
Use this pedigree to organize a hereditary cancer history before a genetics referral.
Dúvidas comuns
What is a hereditary cancer pedigree?
It is a family diagram that records relationships, cancer history and, where known, genetic test status.
What does presymptomatic mean?
It identifies a person with a relevant genetic status who has not developed the recorded condition.
Does this chart diagnose BRCA1?
No. A pedigree supports risk assessment but a diagnosis requires appropriate clinical evaluation and testing.