Prognostic Gene Signature Discovery Pipeline for HCC

シナリオ

A researcher needs a reproducible pipeline to derive a prognostic multigene signature for hepatocellular carcinoma using public transcriptomic cohorts.

この図に含まれるもの

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Use TCGA as the discovery cohort and GEO datasets for independent validation

Apply univariate Cox screening before LASSO to reduce dimensionality

Use Kaplan-Meier separation and independent prognostic evaluation as validation gates

Reusable for similar cancer gene signature discovery workflows where public expression and survival data are available.

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Prognostic Gene Signature Discovery Pipeline for Hepatocellular Carcinoma

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