상황
A researcher needs a reproducible pipeline to derive a prognostic multigene signature for hepatocellular carcinoma using public transcriptomic cohorts.
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01
Use TCGA as the discovery cohort and GEO datasets for independent validation
02
Apply univariate Cox screening before LASSO to reduce dimensionality
03
Use Kaplan-Meier separation and independent prognostic evaluation as validation gates
Reusable for similar cancer gene signature discovery workflows where public expression and survival data are available.