“A Huntington disease pedigree: an affected father and unaffected mother have an affected daughter and an unaffected son; the affected daughter and an unaffected partner have an affected daughter who is the proband and an unaffected son.”
看懂背後的決策。
Affected relatives appear in each generation.
Partners are shown as unaffected.
The affected granddaughter is the proband.
Use this simple chart to introduce autosomal dominant inheritance in a counseling or teaching conversation.
常見問題
What is autosomal dominant inheritance?
A disease-associated variant on a non-sex chromosome can be sufficient to cause the condition.
Why are unaffected relatives included?
They show the family structure and help make the inheritance pattern easier to interpret.
What does the arrow identify?
It marks the proband, the person who prompted the clinical evaluation.